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Selected Recent Publications

I. Shukla, R., Peoples, A.J., Ludwig, K.C., Maity, S., Derks, M.G.N, de Benedetti, S., Krueger, A.M., Vermeulen, B.J.A., Lavore, F., Honorato, R.V., Grein, F., Bonvin, A.M.J.J., Kubitscheck, U., Breukink, E., Achorn, C., Nitti, A., Schwalen, C.J., Spoering, A.L., Ling, L.L., Hughes, D., Lelli, M., Roos, W.H., Lewis, K., Schneider, T., Weingarth, M. (2023) Cell, A new antibiotic from an uncultured bacterium binds to an immutable target

II. Lewis, K., Richard E. Lee, R.E., Brötz-Oesterhelt, H., Hiller Odermatt, S., Rodnina, M., Schneider, T., Weingarth, M., Wolgemuth, I. (2024) Nature, Sophisticated antibiotics from nature, accepted
 

III. Shukla, R., Lavore, Sourav, M., F., Derks, G.N., Jones, C.R., Vermeulen, B.J.A., Melcrova, A., Morris, M.A., Becker, L.M., Wang, X., Kumar, R., Medeiros-Silva, J., van Beekveld, R., Bonvin, A.M.J.J., Lorent, J., Lelli, M., Nowick, J., MacGillavry, H., Peoples, A.J., Spoering, A.L., Ling, L.L., Hughes, Roos, W., D., Breukink, E., Lewis, K., Weingarth, M., (2022) Nature, 608, 390, Teixobactin kills bacteria by a two-pronged attack on the cell envelope

IV.  Jekhmane, S., Derks, M.G.N., Maity, S., Slingerland, C.J.,, Tehrani, K.H.M.E., Medeiros-Silva, J., Vermeer, B., Ammerlaan, D., Charitou, V., Weijde, M., Elenbaas, B.O.W., Fetz, C., Cox, R., Lorent, J.H.F.F., Baldus, M., Künzler, M., Lelli, M., Cochrane, S., Martin, N.I., Roos, W.H., Breukink, E., Weingarth, M., (2024) Nature Microbiology, Host-defense peptide plectasin kills bacteria by a Ca2+-sensitive supramolecular mechanism

 

Full Publications List

63. van Aalst, E.J., Yekefallah, M., van Beekveld, R., Breukink, E., Weingarth, M., Wylie, B. J. (2024) Journal of Structural Biology: X, Coordination of bilayer properties by an inward-rectifier K+ channel is a cooperative process driven by protein-lipid interaction

62. Yekefallah, M., van Aalst, E.J., van Beekveld, R., Breukink, E., Weingarth, M., Wylie, B. J. (2024) J. Am. Chem. Soc., 146, 4421, Cooperative Gating of a K+ Channel by Unmodified Biological Anionic Lipids Viewed by Solid-state NMR Spectroscopy

61. Jekhmane, S., Derks, M.G.N., Maity, S., Slingerland, C.J.,, Tehrani, K.H.M.E., Medeiros-Silva, J., Vermeer, B., Ammerlaan, D., Charitou, V., Weijde, M., Elenbaas, B.O.W., Fetz, C., Cox, R., Lorent, J.H.F.F., Baldus, M., Künzler, M., Lelli, M., Cochrane, S., Martin, N.I., Roos, W.H., Breukink, E., Weingarth, M. (2024) Nature Microbiology, Host-defense peptide plectasin kills bacteria by a Ca2+-sensitive supramolecular mechanism

60. Lewis, K., Richard E. Lee, R.E., Brötz-Oesterhelt, H., Hiller Odermatt, S., Rodnina, M., Schneider, T., Weingarth, M., Wolgemuth, I. (2024) Nature, accepted, Sophisticated antibiotics from nature

59. Ali Javed, A., Balhuizen, M.D., Pannekoek, A., Bikker, F., Heesterbeek, D.A.C., Haagsman, H.P., Broere, F., Weingarth, M., Veldhuizen, E.J.A. (2023) Pharmaceuticals, 16, 1485, Effects of E. coli LPS structure on antibacterial and anti-endo-toxin activities of host defense peptides

58. van der Krift, F. , Zijlmans, D.W., , Shukla, R., , Javed, A., , Koukos, P.I., , Schwarz, L.L.E., , Timmermans-Sprang, E.P.M., , Maas, P.E.M, Gahtory, D., van den Nieuwboer, M., Mol, J.A., Strous, G.J., , Bonvin, A.M.J.J., van der Stelt, M., Veldhuizen, E.J.A, Weingarth, M., Vermeulen, M., Klumperman, Maurice, M.M. (2023) Life Sciences Alliance, A novel antifolate suppresses growth of FPGS-deficient cells and overcomes methotrexate resistance

57. Shukla, R., Peoples, A.J., Ludwig, K.C., Maity, S., Derks, M.G.N, de Benedetti, S., Krueger, A.M., Vermeulen, B.J.A., Lavore, F., Honorato, R.V., Grein, F., Bonvin, A.M.J.J., Kubitscheck, U., Breukink, E., Achorn, C., Nitti, A., Schwalen, C.J., Spoering, A.L., Ling, L.L., Hughes, D., Lelli, M., Roos, W.H., Lewis, K., Schneider, T., Weingarth, M. (2023) Cell, A new antibiotic from an uncultured bacterium binds to an immutable target

56. Javed, A., Slingerland, C.J., Wood, T.M., Martin, N.I., Broere, F., Weingarth, M., Veldhuizen, E.J.A. (2023) ACS Infectious Diseases, 3, 518, A chimeric peptidomimetic antibiotic efficiently neutralizes LPS and bacteria-induced activation of RAW macrophages

55. van Beekveld, R., Derks, D., Kumar, R., Smid, L., Maass, T., Medeiros-Silva, J., Breukink, E., Weingarth, M. (2022) Chemistry – a European Journal, Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy

54. Beek, C., Killian, L., Lutz, M., Weingarth, M., Asundi, A.S., Sarangi, R., Klein Gebbink, R.J.M., Broere, D.L.J. (2022) Chemistry – a European Journal, E-selective Semi-hydrogenation of Alkynes Under Mild Conditions by a Diruthenium Hydride Complex

53. Shukla, R., Lavore, Sourav, M., F., Derks, G.N., Jones, C.R., Vermeulen, B.J.A., Melcrova, A., Morris, M.A., Becker, L.M., Wang, X., Kumar, R., Medeiros-Silva, J., van Beekveld, R., Bonvin, A.M.J.J., Lorent, J., Lelli, M., Nowick, J., MacGillavry, H., Peoples, A.J., Spoering, A.L., Ling, L.L., Hughes, Roos, W., D., Breukink, E., Lewis, K., Weingarth, M. (2022) Nature, 608, 390, Teixobactin kills bacteria by a two-pronged attack on the cell envelope

52. Rončević, T., Gerdol, M., Mardirossian, M., Cvjetan, S., Benincasa, M., Maravić, A., Gajski, G., Krce, L., Aviani, I., Hrabar, J., Pavelin, T., Trumbić, Z., Derks, M., Pallavicini, A., Weingarth, M., Tossi, A., Mladine, I. (2022) Acta Biomaterialia, Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption

51.  Rohaim, A., Vermeulen, B., Li, J., Kümmerer, F., Napoli, F., Blachowicz, Medeiros-Silva, J., Roux., B., Weingarth, M. (2022) Nature Communications, 13, 1574, A distinct mechanism of C-type inactivation in the Kv-like KcsA mutant E71V

50. Zhao, X., Wang., X., Shukla, R., Kumar, R., Weingarth, M., Breukink, E., Kuipers, O. (2021), Frontiers Microbiology, Brevibacillin 2V, a novel antimicrobial lipopeptide with an exceptional low hemolytic activity

49. Zhao, X., Wang., X., Shukla, R., Kumar, R., Weingarth, M., Breukink, E., Kuipers, O. (2021), Frontiers Microbiology, Brevibacillin 2V exerts its bactericidal activity via binding to Lipid II and permeabilizing cellular membranes

48. van Eijk, M., van DIjk, A., van der Ent, C., Arets, H., Breukink, E., van Os, N., Adrichem, R., van der Water, S., Gomez, R.L., Kristensen, M., Hessing, M., Jekhmane, S., Weingarth, M., Veldhuizen, R., Haagsman, H. (2021) BBA – General Subjects, PepBiotics, novel cathelicidin-inspired antimicrobials to fight pulmonary bacterial infections

47. Beriashvili, D., Schellevis, R.D., Napoli, F., Weingarth, M.,* Baldus, M.* (2021) JoVE, accepted, High-resolution studies of proteins in natural membranes by solid-state NMR

46.  Zhai, W., Paioni, L.A., Cai, X., Narasimhan, S., Medeiros-Silva, J., Zhang, W., Rockenbauer, A., Weingarth, M., Song, Y., Baldus., M., Liu, Y. (2020) J. Chem. Phys., 124, 9046, Postmodification via Thiol-click Chemistry Yields Hydrophilic Trityl-nitroxide Biradicals for Biomolecular High-Field Dynamic Nuclear Polarization

45. Lau, Y.J.L., Fontana, F., Mandemaker, L., Wezendonk, D., Vermeer, B., Bonvin, A., de Vries, R., Zhang, H., Remaut, K., van den Dikkenburg, J., Hassan, A., Perrone, B., Kuemmerle, R., Gelain, F., Hennink, W., Weingarth, M.,* Enrico Mastrobattista, E.* (2020), Communications Chemistry, 3, 164, Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides

44. Shukla, S., Medeiros-Silva, J., Parmar, A., Vermeulen, B.J.A., Das, S., Paioni, L.A., Jekhmane, S., Lorent, J., Bonvin, A.M.J.J., Baldus, M., Lelli, M., Veldhuizen, E.J.A., Breukink, E., Singh, I., Weingarth, M. (2020) Nature Comm., 11, 2848,  Mode of action of teixobactins in cellular membranes

43. Bear, B., Veldhuizen, J.A.E., Molchanova, N., Jekhmane, S., Weingarth, M., Jenssen, H., Lin, J.S., Barron, A.E., Yamashita, C., Veldhuizen, R. (2020) Scientific Reports, 10, 9392, Exogeneous Surfacant as a Pulmonary Delivery Vehicle for Chicken Cathelicidin-2

42. Sarkar, D., Chakraborty, I., Condorelli, M., Baijayanti, G., Maass, T., Weingarth, M., Mandal, A.K., La Rosa, C., Subramanian, V., Bhunia, A. (2019) ChemMedChem, Self-assembling and neurotoxicity of amyloid-beta peptide: The crucial role of GXXXG motifs

41. Jekhmane, S., Prachar, M., Fontana, F., Medeiros-Silva, J., Pugliese, R., Gelain, F., Weingarth, M.  (2019) Angew. Chem., 58, 16943, Design parameters of tissue engineering scaffolds at atomic scale

40. Damman, R., Schütz, S., Luo, Y., Prachar, M., Weingarth, M., Sprangers, R., Baldus, M. (2019) Nature Comm., 10, 4536, Atomic-level insight into the maturated state of mRNA processing bodies by combining solid and solution-state NMR spectroscopy

39. Weingarth, M. (2019) Spektrum der Wissenschaft, 3, 20, Angriff auf die Zellmembran

38. Medeiros-Silva, J., Jekhmane, S., Weingarth, M. (2019) ChemBioChem, 14, 1731, Towards the native binding modes of Lipid II targeting antibiotics, invited review for special issue 'ChemBioTalents'

37. Jekhmane, S., Medeiros-Silva, J., Li, J., Kümmerer, F., Müller-Hermes, C., Baldus, M., Roux, B., Weingarth, M. (2019) Nature Comm., 10, 12, Shifts in the selectivity filter dynamics cause modal gating in K+ channels  

36. Medeiros-Silva, J., Jekhmane, S., Lucini Paioni, A., Gawarecka, K., Baldus, M., Swiezewska, E., Breukink, E., Weingarth, M. (2018) Nature Comm., 9, 3963, High-resolution NMR studies of antibiotics in cellular membranes

35. Pinto, C., Mance, D., Sinnige, T., Daniëls, M., Weingarth, M., Baldus, M. (2018) Nature Comm., 9, 4135, The beta-barrel assembly machinery exhibits Conformational Flexibility in lipid bilayers as seen by high-sensitivity solid-state NMR

34. Tikhonova, E., Hariharan, P., Medeiros-Silva, J., Bogdanov, M.V., Dowhan, W., Weingarth, M.,* Guan, L.,* (2018) BMC Biology, 16, 85, Structural and functional characterization of protein-lipid interactions of the Salmonella typhimurium melibiose transporter MelB

33. Saracino, A., Fontana, F., Jekhmane, S., Medeiros-Silva, J., Weingarth, M., Gelain, F. (2018) Advanced Science, 5, 1800471, Elucidating self-assembling peptide aggregation via Morphoscanner: a new tool for protein-peptide structural characterization

32. Pinto, C., Mance, D., Julien, M., Daniëls, M., Weingarth, M., Baldus, M. (2018) J. Struct. Bio., 17, 1047, Studying the assembly of the BAM complex in native membranes by cellular solid-state NMR spectroscopy

31. Visscher, K.M., Medeiros-Silva, J. Mance, D., Rodrigues, J.P.G.L.M., Daniëls, M., Bonvin, A.M.J.J., Baldus, M., Weingarth, M. (2017) Angew. Chem., 56, 13222, Supramolecular organization and functional implications of K+ channel clusters in membranes, Frontispiece article

30. Medeiros-Silva, J., Jekhmane, S., Baldus, M., Weingarth, M. (2017) Solid State Nucl. Magn. Reson., 87, 80, Identifying very strong hydrogen bonds in membrane proteins by time-resolved 1H-detected solid-state NMR and molecular dynamics simulations, invited article special issue ‘Ultra-fast MAS

29. Medeiros-Silva, J., Mance, D., Daniels, M., Jekhmane, S., Houben, K., Baldus, M., Weingarth, M. (2016) Angew. Chem., 55, 13606, 1H- detected solid-state NMR studies of water-inaccessible proteins in vitro and in situ

28. Chung, S., Angelici, C., Hinterding, S.O.M., Weingarth, M., Baldus, M., Houben, K., Weckhuysen, B.M., Bruijnincx, P.C.A. (2016) ACS Catal., 6, 4034, On the role of magnesium silicates in wet-kneaded silica-magnesia catalysts for the Lebedev ethanol-to-butadiene process

27. Mance, D., Sinnige, T., Kaplan, M., Daniels, M., Houben, K., Baldus, M., Weingarth, M. (2015) Angew. Chem., 54, 15799, A labeling approach to harness backbone and side chain protons in 1H-detected solid-state NMR

26. Jantschke, A., Koers, E., Mance, D., Weingarth. M., Brunner, E., Baldus, M. (2015) Angew. Chem., 54, 15069, Insight into the Supramolecular Architecture of Intact Diatom Biosilica Using a DNP-Solid-State NMR-Based Approach

25. Rad Malekshahi, M., Visscher, K.M., Rodrigues, J.P.G.L.M., de Vries, R., Hennink, W.E., Baldus, M., Bonvin, A.M.J.J., Mastrobattista, E., Weingarth, M. (2015) J. Am. Chem. Soc., 137, 7775, The supramolecular organization of a peptide based nanocarrier at high molecular detail 

24. van der Cruijsen, E., Koers, E., Sauvée, C., Hulse, R.E., Weingarth, M., Ouari, O., Perozo, E., Tordo, T., Baldus, M., Chemistry, (2015) Chemistry - A European Journal, 21, 12971, Biomolecular DNP-supported NMR spectroscopy using site directed spin labeling

23. van Zandvoort, I., Koers, E.J., Weingarth, M., Bruijnincx, P.C.A. Baldus, M., Weckhuysen, B.M., (2015) Green Chemistry, 17, 4383, Structural Characterization of 13C-Enriched Humins and Alkali-treated 13C Humins by 2D Solid-state NMR

22. Sinnige, T., Weingarth, M., Daniels, M., Boelens, R., Bonvin, A.M.J.J., Houben, K., Baldus, M., (2015) Structure, 23, 1317, Conformational plasticity of the POTRA 5 domain in the outer membrane protein assembly factor BamA 

21. Koers, E., van der Cruijsen, E., Rosay, M., Weingarth, M., Prokofyev, A., Sauvée, C., Ouari, O., Pongs, O., Tordo, P., Maas, W., Baldus, M. (2014) J. Biomol. NMR, 60, 157, NMR-based Structural Biology enhanced by Dynamic Nuclear Polarization at high magnetic field

20. Sinnige, T., Weingarth, M., Renault, M., Baker, L., Tommassen, J., Baldus, M. (2014) J. Mol. Bio., 426, 2009. Solid-state NMR studies of full-length BamA in lipid bilayers suggest limited overall POTRA mobility

19. Sinnige, T., Daniels, M., Baldus, M., Weingarth, M. (2014) J. Am. Chem. Soc., 136, 4452. Proton clouds to measure non-exchangeable sidechain protons in solid-state NMR, Cover article 

18. Weingarth, M.,* van der Cruijsen, E., Ostmeyer, J., Lievestro, S. Roux, B., Baldus, M.,* (2014) J. Am. Chem. Soc., 136, 2000, Quantitative analysis of the water occupancy around the selectivity filter of a K+ channel in different gating modes *corresponding author

17. Koers, E. J., Lopez-Deber, M. P., Weingarth, M., Nand, D., Hickman, D. T., MlakiNdao, D., Pfeifer, A., Muhs, A., Baldus, M. (2013) Angew. Chem., 52, 10905, Dynamic Nuclear Polarization NMR reveals multiple conformations in lipid-anchored Peptide Vaccines

16. van der Cruijsen, E., Nand, D., Weingarth, M., Prokofyev, A., Hornig, S., Cukkemane, A., Bonvin, A. MMJ, Becker, S., Hulse, R. E., Perozo, E., Pongs, O., Baldus, M. (2013) Proc. Natl. Acad. Sci. USA, 110, 13008. The importance of the lipid-pore loop interface for potassium channel structure and function

15. Weingarth, M., Baldus, M. (2013) Acc. Chem. Res., 46, 2037. Solid-State NMR-Based Approaches for Supramolecular Structure Elucidation

14. Weingarth, M., Prokovyef, A., van der Cruijsen, E., Nand, D., Bonvin, A., Pongs, O., Baldus, M.  (2013) J. Am. Chem. Soc., 135, 10. Structural determinants of specific lipid binding to potassium channels

13. Weingarth, M., Ader, C., Melqiond, A., Nand, D., Becker, S., Bonvin, A., Baldus, M. (2012) Biophys. J., 103, 29. Supramolecular structure of membrane-associated polypeptides by combining solid-state NMR and MD simulations

12. Cukkemane, A., Nand, D., Gradmann, S., Weingarth, M., Baldus, M. (2012) Biomol. NMR Assign. 6, 225, Solid-state NMR [13C,15N] resonance assignments of the nucleotide-binding domain of a bacterial cyclic nucleotide-gated channel

11. Weingarth, M., Trebosc, J., Amoureux, J.P., Bodenhausen, G., Tekely, P. (2011) Solid State Nucl. Magn. Reson. 40, 21. Efficiency at high spinning frequencies of heteronuclear decoupling methods designed to quench rotary resonance

10. Weingarth, M., Masuda, Y., Takegoshi, Bodenhausen, G., Tekely, P. (2011) J. Biol. NMR 50, 129.  Sensitive (13)C- (13)C correlation spectra of amyloid fibrils at very high spinning frequencies and magnetic fields

9. Weingarth, M., Bodenhausen, G. and Tekely, P. (2010) Chem. Phys. Lett. 502, 259, Probing the quenching of rotary resonance by PISSARRO decoupling

8. Weingarth, M., Bodenhausen, G., Tekely, P. (2010) Chem. Phys. Lett. 488, 10, Broadband magnetization transfer using moderate radio-frequency fields for NMR with very high static fields and spinning speeds, Editor’s choice article. 

7. Weingarth, M., Tekely, P., Brüschweiler, R., Bodenhausen, G. (2010) Chem. Comm. 46, 952. Improving the quality of 2D solid-state NMR spectra of microcrystalline proteins by covariance analysis

6. Weingarth, M., Bodenhausen, G., Tekely, P. (2009) J. Am. Chem. Soc. 131, 13937. Broadband carbon-13 correlation spectra of microcrystalline proteins in very high magnetic fields

5. Weingarth, M., Bodenhausen, G., Tekely, P. (2009) J. Magn. Reson. 199, 238. Low-power decoupling at high spinning frequencies in high static fields

4. Weingarth, M., Demco, D., Bodenhausen, G., Tekely, P. (2009) Chem. Phys. Lett. 469, 342. Improved magnetization transfer in solid-state NMR with fast magic angle spinning

3. Rettig, M.*, Weingarth, M.*, Langel, W., Kamal, A., Kumar, P., Weisz, K. (2009) Biochemistry 48, 12223. *co-first authors, Solution structure of a covalently bound pyrrolo-benzodiazepine-benzimidazole hybrid to a 10mer DNA duplex

2. Weingarth, M., Tekely, P., Bodenhausen, G. (2008) Chem. Phys. Lett. 466, 247. Efficient heteronuclear decoupling by quenching rotary resonance in solid-state NMR

1. Weingarth, M., Raouafi, N., Duma, L., Bodenhausen, G., Boujlel, K., Schöllhorn, B., Tekely, P. (2008) Chem. Comm. 45, 5981. Revealing molecular self-assembly and geometry of non-covalent halogen bonding by solid-state NMR spectroscopy

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